10 Steps to Prevent Breast Cancer

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Dr. Ann's 10-Steps to Prevent Breast Cancer

From , About.com Guide

Ann Kulze, M.D. is the author of Dr. Ann's 10-Step Diet (Top Ten Wellness and Fitness, October 2004), a primary care physician, spokesperson for Ruby Tuesday's Restaurant and mother of four. Dr. Ann designed these ten steps to show you how YOU can prevent breast cancer in your life.

1. Maintain a healthy body weight (BMI less than 25) throughout your life. Weight gain in midlife, independent of BMI, has been shown to significantly increase breast cancer risk. Additionally, and elevated BMI has been conclusively shown to increase the risk of post-menopausal breast cancer.

2. Minimize or avoid alcohol. Alcohol use is the most well established dietary risk factor for breast cancer. The Harvard Nurses' Health study, along with several others, has shown consuming more than one alcoholic beverage a day can increase breast cancer risk by as much as 20-25 percent.

3. Consume as many fruits and vegetables as possible. Eat seven or more servings daily. The superstars for breast cancer protection include all cruciferous vegetables (broccoli, cabbage, brussels sprouts, cauliflower) ; dark leafy greens (collards, kale, spinach) ; carrots and tomatoes. The superstar fruits include citrus, berries and cherries. Note: it is best to eat cruciferous vegetables raw or lightly cooked, as some of the phytochemicals believed to offer protection against breast cancer are destroyed by heat.

4. Exercise regularly the rest of your life. Many studies have shown that regular exercise provides powerful protection against breast cancer. Aim for 30 minutes or more of moderate aerobic activity (brisk walking) five or more days a week. Consistency and duration, not intensity, are key!

5. Do your fats right! The type of fat in your diet can affect your breast cancer risk. Minimize consumption of omega-6 fats (sunflower, safflower, corn and cottonseed oils), saturated fats and trans fats. Maximize your intake of omega-3 fats, especially from oily fish (salmon, tuna, mackerel, sardines, lake trout and herring). Consume monounsaturated oils (canola, olive oil, nuts/seeds, avocados) as your primary fat source, as these foods have potential anticancer properties. Specifically, canola oil is a good source of omega-3 fats; extra virgin olive oil is a potent source of antioxidant polyphenols, including squalene; and nuts and seeds provide you with the cancer protective mineral, selenium.

6. Do your carbs right! Minimize consumption of the high glycemic index, "Great White Hazards" - white flour, white rice, white potatoes, sugar and products containing them. These foods trigger hormonal changes that promote cellular growth in breast tissue. Replace these "wrong" carbs with whole grains and beans/legumes. Beans/legumes because of their high fiber and lignan content are especially special.

7. Consume whole food soy products regularly, such as tofu, tempeh, edamame, roasted soy nuts, soy milk and miso. Only consume organic, non-GMO (genetically modified) soy. Epidemiologic studies have shown a positive association between soy consumption and reduced breast cancer risk.

8. Minimize exposure to pharmacologic estrogens and xeno-estrogens. Do not take prescription estrogens unless medically indicated. Lifetime exposure to estrogen plays a fundamental role in the development of breast cancer. Also avoid estrogen-like compounds found in environmental pollutants, such as pesticides and industrial chemicals. Buy organic produce if you can afford it; otherwise, thoroughly wash all non-organic produce. Minimize exposure to residual hormones found in non-organic dairy products, meat and poultry.

9. Take your supplements daily. A multivitamin, 500-1,000 mg of vitamin C in divided doses, 200-400 IUs of vitamin E as mixed tocopherols, and pharmaceutical grade fish oil. Also take 200 mcg of the mineral selenium or eat one to two Brazil nuts as an alternative. If you have a chronic medical condition or take prescription drugs, consult your physician first.

10. Maintain a positive mental outlook. Engage in self-nurturing behaviors regularly. Develop rich, warm and mutually beneficial relationships with family and friends. Get adequate sleep (7-8 hours per night). The mind-body associations with breast cancer are significant.

Seven Secrets About Breast Cancer

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Secret #1 The Money Spent On Research Into Breast Cancer Is Not Ensuring That Less Women Get Breast Cancer.
Secret #2 You Do Need To Act Against Getting Breast Cancer Before You Reach 50 And You Cannot Rely On Mammograms.
Secret #3 You Are At Risk Of Getting Breast Cancer Even If You Don't Have It In Your Family.
Secret #4 Most Of The Money Spent On Research Is Not Going Into Prevention To Ensure That Less Women Suffer The Devastating Effects Of Breast Cancer In The Future.
Secret #5 Most Women Are Not Breast Aware And Are Afraid Of Breast Cancer.
Secret #6 Women Are Not Given Lots Of Advice On How They Can Protect Their Breasts Against Breast Cancer.
Secret #7 Most Women Do Not Appreciate How Important Their Breasts Are And Do Not Do Everything They Can To Look After And Protect Them.

The above "secrets" are things which are not commonly known by most women and may be surprising to you. In this article, I intend to shed light on these facts and allow women to make up their own minds how they approach their breast health.

SECRET #1 THE MONEY SPENT ON RESEARCH INTO BREAST CANCER IS NOT ENSURING THAT LESS WOMEN GET BREAST CANCER.

The Pink Ribbon and Breast Cancer Awarenss Month was introduced in the US in 1985 and introduced to the UK in 1993. The Pink Ribbon Foundation is fronted by the Estee Lauder group of companies (known for cosmetics and skincare).

Since then the pink ribbon symbol has become synonymous with breast cancer and during the past 15 years billions of pounds have been raised in its name. Every October the world celebrates Breast Cancer Awareness Month and fund raising during that month is phenomenal. All the breast cancer charities vie with each other to see who can come up with the most innovative "pink" fundraising. They run pink parties and sell pink products in order to raise money. Many companies take part and do special promotions during October for their preferred charity. "Pink" is big business.

So with all this money being raised during October and also at other times during the year through events like charity runs and walks, is there an impact on the breast cancer rates in the UK and around the world? Are they coming down? Are fewer women suffering from the devastating effects of breast cancer?

Unfortunately, the answer is 'no'.

In the UK, from 1993-2004, breast cancer incidence has increased 18.5%, that is 1% per year. 1 in 9 women will get the disease during their lifetime with current projections of 1 in 7 by 2010. 45,500 women were diagnosed in 2005, which equates to 125 women every day. Worldwide more than a million women are diagnosed with breast cancer every year. It is also projected that breast cancer rates will rise most in developing countries, where women do not have access to top quality care and where they can also be treated as outcasts in certain societies.

Breast cancer survival rates have improved. Every year more than 12,300 women and 70 men die from breast cancer. Since the peak in the late 1980s breast cancer death rates have fallen by a third. Breast cancer drugs have helped to save women's lives but, as with any drugs, can have long-term side affects. Also the cost of these drugs puts great strain on the NHS. If breast cancer rates continue to increase as they have been doing, then, according to Professor Karol Sikora as reported in the Daily Mail on 09/09/08, "the next generation of drugs would keep patients alive longer, but could swallow half of the current NHS cancer budget within four years. (this refers to all cancer drugs at a cost of £50 billion).

With the billions being raised by people around the world in the name of breast cancer, is it right that actually more women are getting this devastating disease every year?

SECRET #2 YOU DO NEED TO ACT AGAINST GETTING BREAST CANCER BEFORE YOU REACH 50 AND YOU CANNOT RELY ON MAMMOGRAMS.

Women in the UK are offered breast screening by mammogram every three years from the age of 50. This is because breast cancer is still more common in women over 50 but also because the breast tissue of younger women is denser and, therefore, makes it more difficult for a mammogram to pick up on a potential breast lump.

However, this could be giving the message to younger women that they don't need to check their breasts themselves. Based on my experience during my breast health talks, very few younger women check their breasts. The main reasons for this are that no-one has shown them how to, they don't know what to do, they think that they only need to worry if breast cancer is in the family (see Secret #3) or they are afraid that they might find something.

For a younger woman it is even more important to check her breasts from her mid-twenties as breast cancer in younger women is usually much more aggressive as the breast cancer cells can multiply more rapidly than in older women. If girls were taught by their mothers to check their breasts from their mid-twenties, they would not be afraid - it would just be part of their general regime of looking after themselves. Also they would feel confident about what to do. Breast self-examination is easy to do once you have been shown how and there are even devices on the market which can help you do so with confidence and greater accuracy.

Breast cancer is the biggest killer of women aged 35-54, which means it makes sense for women in this age bracket to do everything they can to protect their breasts.

Furthermore, I do not believe that we should rely on mammograms either. Women are only screened every three years and, usually, a mammogram can only detect a breast tumour once it has been growing for 8 years. By the time the tumour reaches 10 years, it could be too late. The other thing to remember is that a mammogram can only screen the part of the breast which can be put into the "clamp". It cannot screen under the armpit or between the breasts for example.

Lastly, there is growing concern over the safety of mammograms. The following are extracts from an article written by Peter Leando PhD.

"Controversy has raged for years as to whether the risks related to the radiation exposure suffered from mammography are justified by the benefits gained ...... new evidence relating to the particular type of radiation used and the hard evidence relating to the clinical benefits of mammography have caused a serious re-evaluation of the justification of mammography as a screening test.

Radiation from routine mammography cannot be directly compared to other types of X-ray like chest X-ray etc because they are very different types of radiation.

The comparisons that have been used between a chest x-ray and mammography, 1/1,000 of a rad (radiation-absorbed dose) for a chest X-ray and the 1 rad exposure for the routine four films taken of both breasts for a mammographic screening exam results in some 1,000 times greater exposure. (This refers to the US, where they do four-way screening. In the UK typically only two-way screening is offered.)

This is considered a significant risk factor when extended over a ten year screening period and a potential accumulative dose of 10 rads. Unfortunately this is not the major risk posed by the particular type of radiation used by mammograms, mammography X-rays use a low energy form of ionising radiation that causes greater biologic damage than the high energy X-ray. The very low energy electrons affect the density of ionisation tracks that pass through the tissue, which can cause complex damage to the DNA and carcinogenic changes.

The radiation used by mammography is almost 5 times more effective at causing cancer." So, women do need to start checking their breasts from their early twenties and we cannot rely on mammograms 100%, particularly for younger women who would have a greater exposure to radiation during their lifetime if they were offered mammograms from a younger age. Also mammograms do not detect Inflammatory Breast Cancer (IBC) which is a much rarer form of the disease and does not involve a lump. This would only detected by a woman looking for changes to her breasts and reporting them to her doctor.

SECRET #3 YOU ARE AT RISK OF GETTING BREAST CANCER EVEN IF YOU DON'T HAVE IT IN YOUR FAMILY.

Amongst the hundreds of women I have talked to about breast health, the vast majority were under the false impression that breast cancer is primarily hereditary. They were surprised to hear that fewer than 10% of cases occur to women who have breast cancer in the family.

In fact, every woman is at risk and should take control of her own breast health to give herself the best possible chance of prevention or early detection.

The other most common acknowledged risk factors are:

* Age - breast cancer is more common in women over 50
* Early puberty - it is worrying that puberty is starting younger, with most girls starting their periods at primary school
* Late pregnancy - many woman are opting to have children later
* Late onset menopause
* Not having children and not breastfeeding - this was known as early as the 18th century when a doctor in Italy noticed that nuns had higher levels of breast cancer than the general population
* Being overweight - this applies mainly to post-menopausal women
* Alcohol - over-consumption increases the risk of breast cancer

Acknowledged risk factors account for around 50% of breast cancer cases. For the remainder, there are no definite reasons.

There are a growing number of scientists, commercial companies and individuals who believe that this remaining 50% is due to the rise of the number of chemicals which have been introduced over the past 50 years. They are used in our food, in our toiletries, in the workplace, in our clothes, in our furnishings - in fact, in every aspect of our lives. Many of these chemicals are endocrine disrupting chemicals (EDC's), also known as hormone disruptors or oestrogen mimickers. In simple terms, they act like oestrogen in our bodies and could be responsible for changing our delicate hormone balance which controls events like pregnancy, puberty, menopause.

An interesting example of the levels of oestrogen of British women was examined in a collaborative study undertaken in the late 80's between Oxford University, the Chinese Academy of Preventive Medicine Beijing, Guys, and the Dept. of Preventive Medicine, L.A., California. They compared blood-serum concentrations of hormones linked to breast cancer between women in rural China and in Britain. The results showed that British women who are exposed to toxic chemicals in their everyday lives had increasingly higher levels of oestradiol (oestrogen) than women living a rural lifestyle in China (see table below).

On this theme, the Guardian online reported on 22/05/07 that 'Beijing blames pollutants for rise in killer cancers'.

Oestradiol levels higher in British women by: Age 35 - 44 36% Age 45 - 54 90% Age 55 - 64 171%

SECRET #4 MOST OF THE MONEY SPENT ON RESEARCH IS NOT GOING INTO PREVENTION TO ENSURE THAT FEWER WOMEN SUFFER THE DEVASTATING EFFECTS OF BREAST CANCER IN THE FUTURE.

As we know, billions of pounds are raised every year worldwide in the name of breast cancer and most of this money is received by the mainstream breast cancer charities. In my opinion, the areas which should be targeted by these funds are prevention, treatment and care. You would probably expect these areas, at least, to be treated with equal importance and the funds available allocated accordingly.

Let's first take a look at the mainstream breast cancer charities in this country, namely Cancer Research UK (who obviously deal with all cancers), Breakthrough Breast Cancer, Breast Cancer Campaign and Breast Cancer Care.

Cancer Research UK has done a huge amount of research into breast cancer and their website has a wealth of useful information with a lot of detail on breast cancer. Their slogan is 'Together We Will Beat Cancer'. The charity offers funding schemes to scientists. Their research strategy is directed at reducing mortality from cancer and more women are surviving breast cancer than ever before. Cancer Research UK is looking trying to prevent breast cancer in women known to be at high risk of developing it (approx 10% of sufferers). Doctors have looked into using tamoxifen and other hormone blocking drugs such as anastrozole (Arimidex) to lower the risk of breast cancer in women with a strong family history. This work has to be done very carefully. These women are healthy and the treatment aimed at preventing breast cancer must not risk their health in other ways.

Breakthrough Breast Cancer supports a programme of cutting-edge biological research to reach their vision of 'a future free from the fear of breast cancer'. Breakthrough set up the UK's first dedicated breast cancer research centre in 1999, the Breakthrough Toby Robins Breast Cancer Research Centre. Breakthrough is funding The Generations Study whosepurpose is primarily to investigate environmental, behavioural, hormonal and genetic causes of breast cancer, and secondarily to investigate the causes of other cancers and diseases, by means of a UK cohort study to be established of more than 100,000 women in the UK aged 18 years and older at entry.

However, when you look at environmental factors as a possible risk factor, it seems to be dismissed because it is too difficult to research due to the huge amount of chemicals to which we are exposed in our everyday lives. You can read more at their website under "risk factors".

As I have mentioned, I am one of the many people who believe that certain chemicals which act like oestrogen in our bodies are a contributing factor in rising breast cancer rates. I am disappointed to see that Breakthrough are not even including this as a possible risk factor, particularly as we know that excessive oestrogen has been linked to breast cancer cell growth.

Breast Cancer Campaign cites its mission is to beat breast cancerby funding innovative world-class research to understand how breast cancer develops, leading to improved diagnosis, treatment, prevention and cure. The charity is supporting 97 projects worth over £12.8 million in 41 locations throughout the UK. Over the past 13 years, Campaign has awarded 232 grants with a total value of over £23 million to universities, medical schools / teaching hospitals and research institutes across the UK. Campaign's breast cancer research gap analysis document has been published by the open access journal Breast Cancer Research. The document entitled 'Evaluation of the current knowledge limitations in breast cancer research: a gap analysis' is the product of two and a half year project. It involved around 60 of the key breast cancer scientists in the UK.

Through their website, they sell products of various types and the companies who own those brands donate part of their profits to the Campaign. They include things like lip gloss, perfume, toiletries, clothing and stationery. Some of us would say that many of the products include harmful ingredients and are not actually contributing to the breast health of the ladies buying them! I was also disappointed that, although they mention prevention in their mission statement, I have one of their leaflets that shows prevention only receives 1% of their budget.

Breast Cancer Care, as its name suggests, is primarily concerned with the care and treatment of ladies going through breast cancer. It provides invaluable information and support.

I applaud all of these organisations who are dedicated to their work to help us understand and treat breast cancer.

However, I still believe that the risk factor of certain chemicals affecting our delicate hormone balance should be taken seriously and that all the available research should be studied. It is important to note that only 50% of breast cancer cases can be put down to one of the acknowledged risk factors. What is this remaining 50%? What has changed in our world over the past 50 years? It is also interesting that other countries are recognising the dangers of these chemicals and banning substances. I also believe in adopting the 'precautionary principle', which means that if there is a doubt over the safety to public health, then we should not wait until it is too late but take action as soon as possible. It has also been proved that there are alternatives to these potentially harmful chemicals when we see the growing number of companies who are selling safer food, cosmetics and toiletries.

This is why I am an active supporter of Breast Cancer UK, the only charity whose main focus is primary prevention. We are determined that breast cancer should be a 'preventable' disease not an 'inevitable' one. There is lots of research available on the link between endocrine disrupting chemicals and breast cancer. It is time that this was taken into account when looking at breast cancer risk factors.

SECRET #5 MOST WOMEN ARE NOT BREAST AWARE AND ARE AFRAID OF BREAST CANCER.

Despite the huge focus on being breast aware, particularly during Breast Cancer Awareness month in October, the majority of women are not breast aware. In fact, most women pay little attention to their breasts and do very little to look after them, except maybe during breastfeeding. Our breasts represent our femininity - they make us feel sexy and they nourish our children. Yet most women don't even know what their breasts feel like, let-alone check them for anything unusual.

It is so important that women take control of their own breast health by undertaking monthly self-examination to check for any changes. If they find a lump and go to their doctor straight away, the chances are the lump will be benign (80% are) or, if it is cancerous, they are giving themselves the best possible chance of recovery. At Stage One, women have around a 95% chance of surviving beyond 5 years. At Stage One the lump is less than 2cm and has not spread to the lymph nodes or anywhere else in the body. At Stage Four this survival rate drops to 1 in 10. The average size of lump discovered accidentally by women who don't check their breasts regularly is approximately 3.6 cm.

I have spoken with hundreds of women through my breast education work and most women do not check their breasts because they don't know what to do, they don't realize that all women are at risk, they don't know about the four stages of breast cancer and the corresponding survival rates, they don't really think about the need to do anything to look after their breasts or they are afraid that they might find something.

According to research by Breast Cancer Campaign, breast cancer is the most feared disease amongst women. Fear is usually due to a lack of knowledge. This is certainly the case here. If women understood everything detailed here, they would want to give themselves the best chance of survival should they get the disease. The current approach to women's breast health obviously isn't getting through, which is why I believe it is time to get women to take control themselves and empower other women to do the same.

SECRET #6 WOMEN ARE NOT GIVEN LOTS OF ADVICE ON HOW THEY CAN PROTECT THEIR BREASTS AGAINST BREAST CANCER.

In the past, GP surgeries used to run Well Woman clinics where any woman could go and see a doctor or nurse and be given advice about looking after herself with practical information like being shown how to check her breasts. Very few surgeries offer these clinics now. This is one of the reasons that I started my Breast Health Presentations. I talk to women in the workplace or in other gatherings and empower them with information, which helps to remove some of their fear. I also show them how to check their breasts and talk to them about their bra-wearing habits, how to avoid harmful chemicals in their everyday lives and how to benefit from detoxifying breast massage.

As we know, breast cancer is the most feared disease amongst women and understanding how it develops, the risk factors and, most importantly, how to protect against it, will make women feel more in control and positive towards their breast health.

During October and other events during the year, the focus is on breast cancer rather than breast health. I am one of those people who believe that the more you focus on something negative, the more you will get of it. This is why it is time to change that focus.

I believe that it is definitely time for women to take their breast health into their own hands, which is why I have launched my new campaign "Healthy Breasts For Every Woman". You can read more at www.healthybreastscampaign.co.uk.

SECRET #7 MOST WOMEN DO NOT APPRECIATE HOW IMPORTANT THEIR BREASTS ARE AND DO NOT DO EVERYTHING THEY CAN TO LOOK AFTER AND PROTECT THEM.

As I mentioned before, most women give very little thought to their breasts. They get up in the morning and they may give them a wash in the shower. They then shove them into a cage we call a bra (and most women wear a bra that doesn't fit them properly) and forget about them for the rest of the day. It is amazing that we live in a society which is obsessed with breasts and women do very little to protect this most precious part of their body. It is also amazing that women spend a fortune on looking after every other part of their body with creams and lotions and forget about their breasts! I know that once women understand more about breast health and don't feel so helpless in the face of breast cancer that they do want to be proactive and take control of their breast health.

Nikki Mattei
http://www.bestthinkpink.com

Article Source: http://EzineArticles.com/?expert=Nikki_Mattei

How to Stop Breast Cancer

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How to Stop Breast Cancer
By Egwu Chukwuemeka U. Inya

HOW TO PREVENT CANCER:
We going to talk about how to prevent or reverse cancer with the aid of:

(1) Oxygen
(2) Aerobic exercise
(3) Water
(4) Good nutrition.

Oxygen: The majority of us engage in what is called shallow upper chest breathing: it is difficult to have energy with poor levels of oxygen in our blood stream. The best way to improve the amount of oxygen that flows into our cells is through movement, exercise and breathing techniques using diaphragmatic breathing. It is the best and most efficient way of increasing the flow of energy into our cells. To be healthy we have to improve the quality of our breathing.

If one is diagnosed of cancer, the chances are that the lymph system, the system responsible for elimination of waste is not working effectively. The lymph system relies heavily on exercise, or movement and deep diaphragmatic breathing to function properly.

Food for thought: anytime we feel sluggish or down in energy, 10 minutes of deep diaphragmatic breathing will do the magic of restoration of high energy levels.

Anaerobic exercise: this is another good way of increasing the oxygen levels of the body, it is a form of exercise that increases the heart rate, it can be in form of cycling, walking or swimming at a rate that makes you breath harder and faster.

Water: the cells need water for optimum health both in quality and quantity. Our body is made up of 70% of water, to maintain balance of water one need to be drinking adequate water.
When we are talking about water it does not include fruit juices, sugary drinks, coffee, tea, fizzy drinks or alcohol, what we are advocating is water not fluids.

To cleanse the body, one need's water, water is the number one way to cleanse the body, it is vital for a healthy life, without water we dehydrate both on the inside and outside. The recommended quantity is a minimum of 1-2 liters. Do you know that sometimes you have headache, tiredness and constipation it is a symptom that can be effectively corrected by drinking enough good quality water. Well, when one is involved in an alternative cancer treatment or therapy, standard tap water is not good for it is full of chemicals, in this case what you need is unadulterated water.

Use bottled mineral water with a low sodium content, or use some form of filter jug or under the sink filtration system or alternatively, reverse-osmosis system that is cable of filtering all harmful bacteria, and chemical etc. Also a distillation unit can be used, for those involved in detox regimes, purified water can be bought at the chemist.

Good Nutrition: Nothing can be used to substitute good nutrition as far as the war against cancer through alternative therapy is concerned. "You are what you eat" is a statement of fact. After oxygen and water, good nutrition is the next weapon needed in our arsenal to battle cancer through alternative natural therapy. The assault by free radicals can only be effectively tackled, or reversed, if your body has sufficient concentrations of free radical scavengers, known as antioxidants.

Those experiencing cancer or those who want or are taking the alternative cancer therapy route are hereby advised to desist from eating processed and lifeless foods. Even those undergoing chemotherapy and radiation, the onslaught from this treatment is enough, you don't need to eat food that has no or little nutritional value, stop eating dead foods, if you are undergoing radiation and chemotherapy, dead foods will make your body to be more sicker, it will add more salt to injury.

I repeat, keep away from dead foods such as sugary foods, preservatives, chemicals, crisps, biscuits, in short keep off from McDonald's and all those fast and snappy processed foods. What our body needs to survive the onslaught of cancer and that of chemotherapy and radiation is living foods. Foods that contains a lot of water, natural sugars, vitamins and minerals, fruits vegetables and grasses, this foods can easily be assimilated at a much more faster rate and can keep us vibrantly, healthy.

Yours in the struggle for a cancer free society.

Who wants to prevent or protect him/herself against cancer? Who wants to reverse or cure cancer? If you want to, you are free to visit :the under listed blog where you will have access to various options to that will enable you fight cancer.
Stay positively posted!
Egwu Chukwuemeka U Inya is an alternative Cancer treatment researcher and consultant. He is also a student of Naturopathy. For solutions on how to to protect, reverse, stop or reverse Cancer you are free to visit: http://www.cancersolutions.wordpress.com

cancer prevention

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Cancer prevention: On the horizon
Specialists in cancer prevention are increasingly optimistic about investigations such as the Study of Tamoxifen and Raloxifene (STAR), the Breast Cancer Prevention Trial (BCPT), and the Prostate Cancer Prevention Trial (PCPT). There seem to be many reasons for optimism.
Prostate Cancer Prevention Trial
The PCPT was closed a year ahead of schedule because of its findings showing that men taking finasteride experienced a clear benefit. In brief, investigators randomized 18,882 men aged 55 years and older with normal digital rectal examination findings and prostate-specific antigen (PSA) levels of 3 ng/mL or less to receive 5 mg/d of finasteride or placebo. Follow-up continued for 7 years. Prostate cancer was detected 18.4% of the finasteride group and 24.4% of the placebo group. However, higher-grade tumors (Gleason grade 7, 8, 9, or 10) were more common (37%) in the finasteride than the placebo group (22.2%). Urinary side effects were more common in the placebo group, while sexual side effects caused more difficulties among men in the finasteride group. The investigators concluded that finasteride prevents or delays the appearance of prostate cancer. Many experts are confident that finasteride is a powerful tool against prostate cancer. The Gleason score findings are a cause for further investigation, but because this scoring system was not developed for use in men taking finasteride or other medications, the findings may be artifactual.1 Finasteride causes decreases in prostate volume, which increases the ratio of tumor volume to prostate volume. A reduction in prostate volume, therefore, might increase the risk of finding a high-grade tumor.
The Breast Cancer Prevention Trial
Cancer experts describe the BCPT as "amazing" and "a breakthrough." A test of whether tamoxifen could prevent breast cancer in high-risk women involved more than 13,000 pre- and postmenopausal women at 300 centers in North America. Compared to women who were randomized to receive placebo, women who received tamoxifen had a 49% reduction in breast cancer diagnoses.2
The Study of Tamoxifen and Raloxifene
STAR has enrolled 19,000 postmenopausal women who are at high risk of breast cancer. The efficacy of tamoxifen will be compared to that of raloxifene in preventing breast cancer. Results are expected in mid-2006. The better drug in this trial will eventually compared to an aromatase inhibitor in another breast cancer prevention trial. A related trial, the Capital Area SERM Study, is assessing the efficacy and safety of raloxifene in high-risk premenopausal women.
Selenium and Vitamin E Cancer Prevention Trial
Based on evidence that selenium and vitamin E may significantly lower the risk of prostate cancer, the SELECT trial has enrolled more than 35,000 healthy men who have been randomized to one of the following regimens:
Selenium and vitamin E
Selenium and a placebo
Vitamin E and a placebo
Two placebos
Follow-up is expected to continue for 7 to 12 years. The SELECT trial is notable because 15% of participants are African American. This is a larger percentage than has been enrolled in any other cancer prevention trial.
COX-2 inhibitors, NSAIDS, and vitamin E
Trials of the COX-2 inhibitor celecoxib in the prevention of lung cancer have been resumed after a hiatus caused by the findings that these agents increase the risk of MI. A phase II trial of celecoxib in the prevention of colon cancer in patients with familial adenomatous polyposis is also in progress.
The possible cancer prevention effects of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) have been exceedingly difficult to determine. A new study showed a modest benefit associated with aspirin in preventing prostate cancer.3 A recently published study from the Women's Health Study showed that 10 years of aspirin use had no preventive effects on total, breast, colorectal, or other site-specific cancers.4 Additional data from the Women's Health Study published at the same time showed that vitamin E had no benefit in cancer prevention or the prevention of heart disease.

10th International Lung Cancer Congress

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The Fairmont Orchid
Kohala Coast, HI
Jun 17-20, 2009
Conference Overview
Conference Description & Purpose

Oncology CME-Certified Congress

The purpose of the 10th International Lung Cancer Congress is to update participants on advances in lung cancer, including biology, pathology, staging, individualized therapy, novel agents, and supportive care. The congress will discuss current trends in surgical, radiotherapeutic, and chemotherapeutic approaches to lung cancer and will provide a perspective on clinical data presented at major international oncology meetings. An ongoing focus will be the individualization of therapy based on clinical, histologic, and molecular characteristics. Areas of controversy in lung cancer therapy, including treatment of early-stage and locally advanced disease, testing for molecular markers, and the optimal combination of targeted and cytotoxic agents will be the subject of panel discussions and debates. The congress will also feature presentations on optimizing the application of established targeted agents as well as presentations introducing emerging targeted agents, including mechanisms of action and clinical/preclinical results. A regular feature of the International Lung Cancer Congress is an update of research efforts from major Cooperative Groups in the United States, Europe, and Asia. The format of the meeting will include didactic lectures from internationally renowned leaders, debates and discussions on controversial topics, extensive panel discussions with case scenarios, multidisciplinary tumor boards, and question-and-answer sessions as well as afternoon translational workshops focusing on strategies currently in development for the treatment of lung cancer.

Follow us on Twitter at www.twitter.com/lungcacongress or text “follow lungcacongress” to 40404.
Target Audience
This educational program is directed toward medical oncologists, radiation oncologists, thoracic surgeons, and pulmonologists as well as investigators, practitioners, and fellows in training with research interests in lung cancer. No specific skills or knowledge other than a basic training in oncology is required for successful participation in this activity. Nurses, physician assistants, and other individuals interested in the treatment of lung cancer are also invited to attend.
Learning Objectives

At the conclusion of this congress, you should be able to:

* Summarize clinical data on the efficacy of adjuvant/neoadjuvant chemotherapy for patients with early-stage NSCLC
* Compare the predictive power of tumor stage and molecular profiling in early-stage NSCLC
* Review current issues in the surgical treatment of NSCLC
* Evaluate clinical data on radiation therapy in the treatment of early-stage and locally advanced NSCLC
* Describe combined modality approaches for patients with locally advanced lung cancer
* Assess the feasibility of sublobar resections in early-stage NSCLC
* Summarize the impact of revised staging criteria on lung cancer diagnosis
* Discuss the optimal application of antiangiogenic agents in lung cancer
* Assess approaches to managing toxicities from antiangiogenic agents
* Discuss updates on the use of EGFR TKIs, including the impact of molecular and clinical characteristics and overcoming resistance
* Evaluate clinical data on anti-EGFR antibodies in NSCLC treatment regimens
* Assess clinical data on multikinase inhibitors and epigenetic approaches
* Evaluate approaches to optimize lung cancer therapy based on clinical and molecular characteristics
* Discuss pathologic approaches to categorize lung cancers histologically and molecularly
* Evaluate clinical data on agents used to ameliorate bone health in patients with lung cancer
* Discuss novel cytotoxic and other targeted agents in development for patients with lung cancer
* Evaluate approaches to improve outcomes with frontline and salvage therapy regimens in metastatic NSCLC
* Summarize current research activity in lung cancer from national and regional Cooperative Group

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